GBL EFFECTS

Gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) are prodrugs for gamma-hydroxybutyrate (GHB). Like GHB, GBL and 1,4-BD are drugs of abuse, but their behavioral effects may differ from GHB under some conditions. Objectives The first study compared the behavioral effects of GBL (32−240 mg/kg) and 1,4-BD (32−240 mg/kg) with each other and to effects previously reported for …

Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL)Behavioral effects and pharmacokinetics  Read More »

Gamma-hydroxybutyrate (GHB) is a naturally occurring endogenous compound, related to the inhibitory neurotransmitter, gamma-aminobutyric acid (GABA). It was synthesized for use as an anaesthetic agent in the 1960s, but it did not become an established agent due to adverse effects including nausea, vomiting and seizure-like activity.1,2 Over the next few decades, GHB first became abused by …

Medical and legal confusion surrounding gamma-hydroxybutyrate (GHB) and its precursors gamma-butyrolactone (GBL) Read More »